Surface Plasmon Resonance

A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.

Year introduced: 1999

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Tree Number(s): E05.196.890, E05.601.043.700

MeSH Unique ID: D020349

Entry Terms:

• Plasmon Resonances, Surface
• Plasmon Resonance, Surface
• Resonances, Surface Plasmon
• Resonance, Surface Plasmon
• Surface Plasmon Resonances

Previous Indexing:

• Biosensing Techniques (1991-1998)

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Chemistry Techniques, Analytical
Surface Plasmon Resonance

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Molecular Probe Techniques
Biosensing Techniques
Surface Plasmon Resonance