Thiorphan

A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.

Year introduced: 1989

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Tree Number(s): D02.886.030.893, D12.125.166.893, D12.125.481.700.750

MeSH Unique ID: D015244

Registry Number: B79L7B5X3Z

Entry Terms:

• (3-Mercapto-2-benzylpropionyl)glycine
• Tiorphan
• Thiorphan, (R)-Isomer
• Thiorphan, (S)-Isomer

Previous Indexing:

• Mercaptopropionylglycine/analogs and derivatives (1980-1988)

Pharmacologic Action:

• Protease Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Organic Chemicals
Sulfur Compounds
Amino Acids, Sulfur
Thiorphan

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Amino Acids
Amino Acids, Sulfur
Thiorphan

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Amino Acids
Glycine
N-substituted Glycines
Thiorphan