Captopril

A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.

Year introduced: 1986(1980)

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Tree Number(s): D12.125.072.401.623.270

MeSH Unique ID: D002216

Registry Number: 9G64RSX1XD

Entry Terms:

• (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
• SQ-14,534
• SQ 14,534
• SQ14,534
• SQ-14534
• SQ14534
• SQ 14534
• Capoten
• Lopirin
• SQ-14,225
• SQ 14,225
• SQ14,225
• SQ-14225
• SQ14225
• SQ 14225

Previous Indexing:

• Kininase II/antagonists and inhibitors (1973-1979)
• Peptide Peptidohydrolases (1966-1967) /antagonists and inhibitors (1968-1972)
• Proline (1966-1974) /antagonists and inhibitors (1975-1979)

Pharmacologic Action:

• Angiotensin-Converting Enzyme Inhibitors
• Antihypertensive Agents

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Amino Acids
Amino Acids, Cyclic
Imino Acids
Proline
Captopril