eIF-2 Kinase
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
Year introduced: 1998
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Subheadings:
Tree Number(s): D08.811.913.696.620.682.700.300, D12.776.476.563.300
MeSH Unique ID: D019892
Registry Number: EC 2.7.11.1
Entry Terms:
- eIF 2 Kinase
- Kinase, eIF-2
- Hemin-Controlled Translational Repressor
- Hemin Controlled Translational Repressor
- Repressor, Hemin-Controlled Translational
- Translational Repressor, Hemin-Controlled
- Eukaryotic Initiation Factor 2alpha Kinase
- Heme Controlled Repressor
- Controlled Repressor, Heme
- Repressor, Heme Controlled
- Heme-Controlled Inhibitor
- Heme Controlled Inhibitor
- Inhibitor, Heme-Controlled
- Heme-Regulated eIF-2alpha Kinase
- eIF-2alpha Kinase, Heme-Regulated
- Heme Regulated eIF 2alpha Kinase
- Kinase, Heme-Regulated eIF-2alpha
- Hemin Controlled Repressor
- Controlled Repressor, Hemin
- Repressor, Hemin Controlled
- p68 Kinase
- Kinase, p68
- Self-Phosphorylating Protein Kinase
- Kinase, Self-Phosphorylating Protein
- Protein Kinase, Self-Phosphorylating
- Self Phosphorylating Protein Kinase
- TIK Kinase
- Kinase, TIK
- P68 Protein Kinase
- Kinase, P68 Protein
- Protein Kinase, P68
- RNA-Dependent Protein Kinase
- Kinase, RNA-Dependent Protein
- Protein Kinase, RNA-Dependent
- RNA Dependent Protein Kinase
- p65 Kinase
- Kinase, p65
- Protein Kinase PKR
- Kinase PKR, Protein
- PKR, Protein Kinase
- Protein Kinase, RNA Activated
- Heme-Controlled Translational Repressor
- Heme Controlled Translational Repressor
- Repressor, Heme-Controlled Translational
- Translational Repressor, Heme-Controlled
- DAI Protein Kinase
- Kinase, DAI Protein
- Protein Kinase, DAI
- Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase
- Double Stranded RNA Dependent eIF 2 alpha Protein Kinase
- Double Stranded RNA-Dependent Kinase (dsl)
- dsRNA-Activated Inhibitor
- dsRNA Activated Inhibitor
- Inhibitor, dsRNA-Activated
- DSRNA-Dep Protein Kinase
- DSRNA Dep Protein Kinase
- Kinase, DSRNA-Dep Protein
- Protein Kinase, DSRNA-Dep
- eIF-2alpha Kinase
- eIF 2alpha Kinase
- Kinase, eIF-2alpha
- eRF, eIF-2 Recycling Factor
- eRF, eIF 2 Recycling Factor
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