Proteus Syndrome

Hamartoneoplastic malformation syndrome of uncertain etiology characterized by partial GIGANTISM of the hands and/or feet, asymmetry of the limbs, plantar hyperplasia, hemangiomas (HEMANGIOMA), lipomas (LIPOMA), lymphangiomas (LYMPHANGIOMA), epidermal NEVI; MACROCEPHALY; cranial HYPEROSTOSIS, and long-bone overgrowth. Joseph Merrick, the so-called elephant man, apparently suffered from Proteus syndrome and not NEUROFIBROMATOSIS, a disorder with similar characteristics.

Year introduced: 1992

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Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): C04.445.435.500, C04.651.435.500, C05.116.099.750, C05.660.585.620, C16.131.077.740, C16.131.621.585.620

MeSH Unique ID: D016715

Entry Terms:

• Elephant Man Disease
• Proteus-Like Syndrome
• Proteus Like Syndrome
• Syndrome, Proteus-Like

Previous Indexing:

• Abnormalities, Multiple (1979-1991)
• Neoplasms, Multiple Primary (1986-1991)
• Neurofibromatosis 1 (1979-1990)

All MeSH Categories
Diseases Category
Neoplasms
Hamartoma
Hamartoma Syndrome, Multiple
Proteus Syndrome

All MeSH Categories
Diseases Category
Neoplasms
Neoplasms, Multiple Primary
Hamartoma Syndrome, Multiple
Proteus Syndrome

All MeSH Categories
Diseases Category
Musculoskeletal Diseases
Bone Diseases
Bone Diseases, Developmental
Proteus Syndrome

All MeSH Categories
Diseases Category
Musculoskeletal Diseases
Musculoskeletal Abnormalities
Limb Deformities, Congenital
Proteus Syndrome

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Congenital Abnormalities
Abnormalities, Multiple
Proteus Syndrome

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Congenital Abnormalities
Musculoskeletal Abnormalities
Limb Deformities, Congenital
Proteus Syndrome