Mutagenesis, Insertional
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
Year introduced: 1991
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Subheadings:
Tree Number(s): E05.393.420.601.550, G05.365.590.575, G05.558.550
MeSH Unique ID: D016254
Entry Terms:
- Insertional Mutagenesis
- Linker-Insertion Mutagenesis
- Linker Insertion Mutagenesis
- Mutagenesis, Linker-Insertion
- Mutagenesis, Cassette
- Cassette Mutagenesis
- Viral Insertional Mutagenesis
- Insertional Mutagenesis, Viral
- Mutagenesis, Viral Insertional
- Gene Insertion
- Gene Insertions
- Insertion, Gene
- Insertions, Gene
- Insertion Mutation
- Insertion Mutations
- Mutation, Insertion
- Mutations, Insertion
- Insertional Activation
- Activation, Insertional
- Activations, Insertional
- Insertional Activations
- Sequence Insertion
- Insertion, Sequence
- Insertions, Sequence
- Sequence Insertions
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