Thalidomide

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.

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Tree Number(s): D02.241.223.805.810.800, D03.383.621.808.800, D03.633.100.513.750.750

MeSH Unique ID: D013792

Registry Number: 4Z8R6ORS6L

Entry Terms:

• Sedoval
• Thalomid

Pharmacologic Action:

• Immunosuppressive Agents
• Leprostatic Agents
• Teratogens
• Angiogenesis Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Organic Chemicals
Carboxylic Acids
Acids, Carbocyclic
Phthalic Acids
Phthalimides
Thalidomide

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, 1-Ring
Piperidines
Piperidones
Thalidomide

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, Fused-Ring
Heterocyclic Compounds, 2-Ring
Isoindoles
Phthalimides
Thalidomide