Gene Amplification

A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.

Year introduced: 1980

PubMed search builder options

Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): G05.308.250, G05.365.590.310, G05.558.315

MeSH Unique ID: D005784

Entry Terms:

• Amplification, Gene

Previous Indexing:

• Genes (1966-1967)
• Genes, Structural (1968-1979)
• Nucleic Acid Hybridization (1971-1979)
• Plasmids (1975-1979)

See Also:

• Gene Dosage

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Gene Expression Regulation
Gene Amplification

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Genetic Variation
Mutation
Gene Amplification

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Mutagenesis
Gene Amplification