Mannose-Binding Protein Deficiency [Supplementary Concept]
A condition characterized by a mannose-binding lectin (MBL) protein level of less than 100 ng/ml, that occurs in about 5% of people of European descent and in about 10% of sub-Saharan Africans. Most MBL-deficient adults appear healthy, but low levels of MBL are associated with increased risk of infection in toddlers, in cancer patients undergoing chemotherapy, and in organ-transplant patients receiving immunosuppressive drugs, particularly recipients of liver transplants. Polymorphisms in the MBL2 gene have been identified. OMIM: 614372
Date introduced: November 5, 2012
MeSH Unique ID: C563602
Heading Mapped to:
Entry Terms:
- Mannose-Binding Lectin Deficiency
- Mannose-Binding Lectin Protein Deficiency
- MBL2 Deficiency
- MBP Deficiency
- MBL Deficiency