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V(D)J Recombination
The process by which the V (variable), D (diversity), and J (joining) segments of IMMUNOGLOBULIN GENES or T-CELL RECEPTOR GENES are assembled during the development of LYMPHOID CELLS using NONHOMOLOGOUS DNA END-JOINING.
Year introduced: 2012
Immunoglobulin J-Chains
A 15 kDa joining peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains.
Year introduced: 2006 (1974)
Immunoglobulin J Recombination Signal Sequence-Binding Protein
A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS.
Year introduced: 2006(1992)
Hemoglobin J
A group of abnormal hemoglobins with similar electrophoretic characteristics. They have faster electrophoretic mobility and different amino acid substitutions in either the alpha or beta chains than normal adult hemoglobin. Some of the variants produce hematologic abnormalities, others result in no clinical disorders.
Year introduced: 1991(1977)
dibenz(a,j)anthracene-3,4-diol-1,2-epoxide [Supplementary Concept]
structure given in first source
Date introduced: January 11, 1989
J 114870 [Supplementary Concept]
structure in first source
Date introduced: March 3, 2000
VDJ Recombinases
Recombinases involved in the rearrangement of immunity-related GENES such as IMMUNOGLOBULIN GENES and T-CELL RECEPTOR GENES.
Year introduced: 2004
9,10-dihydro-9,10-dihydroxybenzo(j)fluoranthene [Supplementary Concept]
structure in first source; RN refers to cpd with no isomeric designation
Date introduced: March 23, 1994
4,5-dihydro-4,5-dihydroxybenzo(j)fluoranthene [Supplementary Concept]
hemoglobin J Guantanamo [Supplementary Concept]
alanine replaced by aspartic acid at position alpha2beta2 128(H6)
Date introduced: August 3, 1988
Kcnj10 (channel) [Supplementary Concept]
Date introduced: September 29, 2004
J 111225 [Supplementary Concept]
J 111347 [Supplementary Concept]
PMAI protein, Parietaria judaica [Supplementary Concept]
capable of interacting with IgE; amino acid sequence given in first source
Date introduced: April 29, 1997
uK-ATP-1 potassium channel [Supplementary Concept]
a 48 kDa pore that interacts with sulfonylurea receptor to form KATP channels; found in various tissues; GenBank D42145; KCNJ8 - human; RefSeq NM_004982 (human), NM_008428 (mouse), NM_017099 (rat)
Date introduced: April 14, 1995
Bra j protein, Brassica juncea [Supplementary Concept]
a major allergen (2 S albumin) from oriental mustard (Brassica juncea) seeds; recognized by human IgE from mustard-sensitive individuals; closely related to major allergen Sin a I from yellow mustard seeds; MW about 16,000
Date introduced: April 29, 1992
RAG-1 protein [Supplementary Concept]
mediates V(D)J recombination; expressed exclusively in maturing lymphoid cells; amino acid sequence is known; RefSeq NM_000448 (human), NM_009019 (mouse); GenBank U71093 (Zebrafish)
Date introduced: July 30, 1990
3,4-dihydrodiol-7,14-dimethylbenz(a,j)anthracene [Supplementary Concept]
RN given refers to parent cpd; RN & structure given in first source
Date introduced: August 4, 1988
3,4-dihydrodioldibenz(a,j)anthracene [Supplementary Concept]
hemoglobin J-Paris [Supplementary Concept]
alanine at position 12 of alpha chains is replaced by aspartic acid
Date introduced: September 29, 1986