Genes, BRCA2

A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)

Year introduced: 2002

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Tree Number(s): G05.360.340.024.340.375.249.105, G05.360.340.024.340.415.400.105

MeSH Unique ID: D024522

Entry Terms:

• BRCA2 Genes
• Gene, BRCA2
• BRCA2 Gene

Previous Indexing:

• Genes, Tumor Suppressor (1995-2001)

See Also:

• BRCA2 Protein

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Genetic Structures
Genome
Genome Components
Genes
Genes, Neoplasm
Genes, Tumor Suppressor
Genes, BRCA2

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Genetic Structures
Genome
Genome Components
Genes
Genes, Recessive
Genes, Tumor Suppressor
Genes, BRCA2