Lambert-Eaton Myasthenic Syndrome
An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)
Year introduced: 1990
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Tree Number(s): C04.588.614.550.500.225, C04.730.856.490.225, C10.114.656.150, C10.574.781.588.225, C10.668.758.725.150, C20.111.258.500.150
MeSH Unique ID: D015624
Entry Terms:
- Lambert Eaton Myasthenic Syndrome
- Myopathic-Myasthenic Syndrome of Eaton-Lambert
- Eaton-Lambert Myopathic-Myasthenic Syndrome
- Eaton-Lambert Myopathic-Myasthenic Syndromes
- Myopathic Myasthenic Syndrome of Eaton Lambert
- Myopathic-Myasthenic Syndrome of Lambert-Eaton
- Lambert-Eaton Myopathic-Myasthenic Syndrome
- Lambert-Eaton Myopathic-Myasthenic Syndromes
- Lambert-Eaton Syndrome
- Lambert Eaton Syndrome
- Syndrome, Lambert-Eaton
- Eaton-Lambert Syndrome
- Eaton Lambert Syndrome
- Syndrome, Eaton-Lambert
- Eaton-Lambert Myasthenic Syndrome
- Eaton Lambert Myasthenic Syndrome
- Myasthenic Syndrome, Eaton-Lambert
- Syndrome, Eaton-Lambert Myasthenic
- Myasthenic Syndrome, Lambert-Eaton
- Myasthenic Syndrome, Lambert Eaton
- Syndrome, Lambert-Eaton Myasthenic
- Myasthenic-Myopathic Syndrome of Lambert-Eaton
- Lambert-Eaton Myasthenic-Myopathic Syndrome
- Lambert-Eaton Myasthenic-Myopathic Syndromes
- Myasthenic Myopathic Syndrome of Lambert Eaton
- Myasthenic-Myopathic Syndrome of Eaton-Lambert
- Eaton-Lambert Myasthenic-Myopathic Syndrome
- Myasthenic Myopathic Syndrome of Eaton Lambert
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