Mirtazapine

A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.

Year introduced: 2019 (1982)

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Tree Number(s): D03.633.300.240.588

MeSH Unique ID: D000078785

Registry Number: A051Q2099Q

Entry Terms:

• 6-Azamianserin
• 6 Azamianserin
• Remeron
• Zispin
• Norset
• Remergil
• ORG 3770
• ORG-3770
• ORG3770
• Rexer
• Esmirtazapine
• (S)-Mirtazapine
• Org 50081
• (N-Methyl-11C)mirtazapine

Pharmacologic Action:

• Antidepressive Agents
• Histamine H1 Antagonists
• Anti-Anxiety Agents
• Adrenergic alpha-2 Receptor Antagonists
• Serotonin 5-HT2 Receptor Antagonists
• Serotonin 5-HT3 Receptor Antagonists

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, Fused-Ring
Heterocyclic Compounds, 3-Ring
Dibenzazepines
Mirtazapine