Tolvaptan

A benzazepine derivative and selective VASOPRESSIN V2 RECEPTOR antagonist that is used to treat euvolemic and hypervolemic HYPONATREMIA. It is also used in the treatment of rapidly progressing AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE to slow the rate of cyst development and renal insufficiency.

Year introduced: 2019 (1999)

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Tree Number(s): D03.633.100.079.875

MeSH Unique ID: D000077602

Registry Number: 21G72T1950

Entry Terms:

• 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
• OPC 41061
• OPC-41061
• OPC41061
• Samsca

Pharmacologic Action:

• Antidiuretic Hormone Receptor Antagonists

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, Fused-Ring
Heterocyclic Compounds, 2-Ring
Benzazepines
Tolvaptan