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3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21)
Year introduced: 2002(1998)
Catechol 2,3-Dioxygenase
Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 1.13.1.2.
Year introduced: 2006(1981)
Protocatechuate-3,4-Dioxygenase
An enzyme that catalyzes the oxidation of protocatechuate to 3-carboxy-cis-cis-muconate in the presence of molecular oxygen. It contains ferric ion. EC 1.13.11.3.
Year introduced: 1991(1975)
1-amino-1,3-dicarboxycyclopentane [Supplementary Concept]
RN given refers to (cis)-isomer
Date introduced: December 13, 1982
3-methylfentanyl [Supplementary Concept]
RN given refers to parent cpd without isomeric designation
Date introduced: July 30, 1981
1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline [Supplementary Concept]
RN given refers to parent cpd
Date introduced: September 13, 1990
3-aminocyclopentane-1-carboxylic acid [Supplementary Concept]
structure given in first source; a selective GABA-A agonist; a cyclopentane analog of GABA; RN given for (trans)-isomer
Date introduced: August 4, 1992
platinum(II) 1,2-diaminocyclohexane malonate [Supplementary Concept]
RN given refers to (SP-4-2-(trans))-isomer
Date introduced: January 1, 1976
dichloro-1-hydroxy-3,4-diaminocyclohexane platinum complex [Supplementary Concept]
structure given in first source; RN given refers to the (1alpha,3beta,4beta)-isomer
Date introduced: February 1, 1989
3-phenyl-3-(N-piperidinyl)bicyclo(3.1.0)hexane [Supplementary Concept]
RN & structure given in first source; RN given refers to (cis)-isomer; RN for cpd without isomeric designation not available 9/88
Date introduced: September 1, 1988
Oxaliplatin
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
Year introduced: 2019 (1981)
1-phenyl-3-(3-methoxy-2-propoxy-5-(4-(3,4,5-trimethoxyphenyl)-1,3-dithiolane-2-yl)phenyl)thiourea [Supplementary Concept]
increases production of nitric oxide; ZX-4 and ZX-5 are the (cis)- and (trans)-isomers, respectively; structure in first source
Date introduced: January 23, 2004
Catechin
An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
Year introduced: 1987(1977)
1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane [Supplementary Concept]
may be highly effective in treatment of estrogen-dependent breast cancer; structure given in first source; RN given refers to the (cis)-isomer
Date introduced: August 1, 1992
dichloro-1,2-diaminocyclohexane platinum complex [Supplementary Concept]
RN given refers to (SP-4-2)-isomer
Date introduced: January 1, 1977
abrocitinib [Supplementary Concept]
Janus kinase 1 inhibitor
Date introduced: September 23, 2019
3-iododizocilpine [Supplementary Concept]
RN given for (+-)-isomer,125I-labeled cpd; structure in first source
Date introduced: June 6, 1997
dicarbine [Supplementary Concept]
minor descriptor (77-84); on-line & Index Medicus search CARBOLINES (77-84); RN given refers to parent cpd without isomeric designation
Date introduced: August 10, 1984
2,3,3a,4,5,9b-hexahydro-1-methyl-1H-pyrrolo(3,2-h)isoquinoline [Supplementary Concept]
a bridged nicotine analog; structure given in first source; RN given refers to (cis-(+-))-isomer
Date introduced: December 9, 1993
7-(3-amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-1,4-dihydro-6-fluoro-8-methyl-4-oxoquinoline-3-carboxylic acid [Supplementary Concept]
structure given in first source; RN given is for cis isomer
Date introduced: March 21, 1991