1,2-Dibutan-2-ylhydrazine - MeSH

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The following terms were not found in MeSH: Dibutan, ylhydrazine, 2-Dibutan-2-ylhydrazine.

Select item 680131841.

5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole

A nitrovinyl furan used as a schistosomicidal agent and proposed for trypanosomiasis, especially Chagas disease.

Year introduced: 2005(1975)

Select item 680123692.

2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-

Proposed catecholamine depletor.

Year introduced: 2005(1988)

Select item 680014983.

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester

A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.

Year introduced: 1987

Select item 680173014.

Ca(2+) Mg(2+)-ATPase

An enzyme that catalyzes the hydrolysis of ATP and is activated by millimolar concentrations of either Ca(2+) or Mg(2+). Unlike CA(2+)-TRANSPORTING ATPASE it does not require the second divalent cation for its activity, and is not sensitive to orthovanadate. (Prog Biophys Mol Biol 1988;52(1):1). A subgroup of EC 3.6.1.3.

Year introduced: 1993

Select item 680571255.

Nuclear Receptor Subfamily 2, Group C, Member 2

An orphan nuclear receptor that has specificity for hormone response elements found in the promoters of target genes. It binds DNA either as a homodimer or as heterodimer with the closely-related orphan nuclear receptor NUCLEAR RECEPTOR SUBFAMILY 2, GROUP C, MEMBER 1. The protein was originally identified as a TESTES-specific protein and is involved in the regulation of variety of cellular processes, including CELL DIFFERENTIATION; CELL PROLIFERATION; and APOPTOSIS.

Year introduced: 2010

Select item 680156326.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.

Year introduced: 1990

Select item 680505487.

Catechol 1,2-Dioxygenase

An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC 1.13.1.1 and EC 1.99.2.2.

Year introduced: 2006(1980)

Select item 680505608.

Homogentisate 1,2-Dioxygenase

A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.

Year introduced: 2006(1969)

Select item 680571079.

Nuclear Receptor Subfamily 2, Group C, Member 1

A DNA-binding orphan nuclear receptor that has specificity for directly repeated (DR) AGGTCA sequences. It binds DNA as either as a homodimer or as a heterodimer with the closely-related orphan nuclear receptor NUCLEAR RECEPTOR SUBFAMILY 2, GROUP C, MEMBER 2. The protein was originally identified as a PROSTATE-specific protein and is involved in the regulation of variety of cellular processes, including CELL DIFFERENTIATION; CELL PROLIFERATION; and APOPTOSIS.

Year introduced: 2010(1995)

Select item 6804320310.

1-Alkyl-2-acetylglycerophosphocholine Esterase

A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.

Year introduced: 2004(1983)

Select item 201647211.

Src Homology 2 Domain-Containing, Transforming Protein 1

An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.

Year introduced: 2017

Select item 6806102712.

Programmed Cell Death 1 Ligand 2 Protein

A costimulatory B7 antigen that has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 RECEPTOR. It is closely-related to CD274 antigen; however, its expression is restricted to DENDRITIC CELLS and activated MACROPHAGES.

Year introduced: 2012(2001)

Select item 6801990013.

3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer

A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21)

Year introduced: 2002(1998)

Select item 6805709514.

Nuclear Receptor Subfamily 1, Group F, Member 2

An orphan nuclear receptor that is expressed at high levels in neuronal tissues, the RETINA; EPIDIDYMIS; and VAS DEFERENS. The receptor is believed to play a role in regulating a variety of functions including the processing of sensory information, the differentiation of PHOTORECEPTOR CELLS and the CIRCADIAN RHYTHM.

Year introduced: 2010(1998)

Select item 6801981315.

1,2-Dimethylhydrazine

A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.

Year introduced: 1998

Select item 6801930716.

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine

A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.

Year introduced: 1997

Select item 6801564717.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine

A selective D1 dopamine receptor agonist used primarily as a research tool.

Year introduced: 2005(1990)

Select item 6801512718.

9,10-Dimethyl-1,2-benzanthracene

Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.

Year introduced: 1985(1975)

Select item 6801506019.

1,2-Dipalmitoylphosphatidylcholine

Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.