Sotos Syndrome

Congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.

Year introduced: 2011

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Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): C16.131.077.889, C16.131.260.905, C16.320.180.905

MeSH Unique ID: D058495

Entry Terms:

• Syndrome, Sotos
• Cerebral Gigantism
• Cerebral Gigantisms
• Gigantism, Cerebral
• Gigantisms, Cerebral
• Sotos Sequence
• Sequence, Sotos
• Sotos' Syndrome
• Soto's Syndrome
• Soto Syndrome
• Syndrome, Sotos'

Previous Indexing:

• Acromegaly (1977-2010)
• Gigantism (1977-2010)

See Also:

• Fetal Macrosomia
• Gigantism

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Congenital Abnormalities
Abnormalities, Multiple
Sotos Syndrome

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Congenital Abnormalities
Chromosome Disorders
Sotos Syndrome

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Genetic Diseases, Inborn
Chromosome Disorders
Sotos Syndrome