Donohue Syndrome

Rare autosomal recessive syndrome of extreme insulin resistance due to mutations in the binding domain of INSULIN RECEPTOR. Clinical features include severe intrauterine and postnatal growth restriction, characteristic dysmorphic FACIES; HIRSUTISM; VIRILIZATION; multiple endocrine abnormalities, and early death.

Year introduced: 2010

PubMed search builder options

Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): C05.660.207.325, C16.131.077.313, C16.320.215, C18.452.394.750.654, C19.246.537

MeSH Unique ID: D056731

Entry Terms:

• Syndrome, Donohue
• Leprechaunism
• Leprechaunisms
• Rabson-Mendenhall Syndrome
• Rabson Mendenhall Syndrome
• Syndrome, Rabson-Mendenhall
• Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities
• Mendenhall Syndrome
• Syndrome, Mendenhall

Previous Indexing:

• Abnormalities, Multiple (2002-2009)
• Acanthosis Nigricans (2002-2009)
• Diabetes Mellitus (2000-2009)

See Also:

• Insulin Resistance
• Receptor, Insulin

All MeSH Categories
Diseases Category
Musculoskeletal Diseases
Musculoskeletal Abnormalities
Craniofacial Abnormalities
Donohue Syndrome

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Congenital Abnormalities
Abnormalities, Multiple
Donohue Syndrome

All MeSH Categories
Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Genetic Diseases, Inborn
Donohue Syndrome

All MeSH Categories
Diseases Category
Nutritional and Metabolic Diseases
Metabolic Diseases
Glucose Metabolism Disorders
Diabetes Mellitus
Donohue Syndrome

All MeSH Categories
Diseases Category
Endocrine System Diseases
Diabetes Mellitus
Donohue Syndrome