Janus Kinases

A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains.

Year introduced: 2007

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Tree Number(s): D08.811.913.696.620.682.725.124, D12.776.476.568.124

MeSH Unique ID: D053612

Registry Number: EC 2.7.10.2

Entry Terms:

• Kinases, Janus
• Janus Kinase
• Kinase, Janus
• JAK Kinases
• Kinases, JAK

See Also:

• src Homology Domains

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Phosphotransferases
Phosphotransferases (Alcohol Group Acceptor)
Protein Kinases
Protein-Tyrosine Kinases
Janus Kinases
Janus Kinase 1
Janus Kinase 2
Janus Kinase 3
TYK2 Kinase

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Protein-Tyrosine Kinases
Janus Kinases
Janus Kinase 1
Janus Kinase 2
Janus Kinase 3
TYK2 Kinase