alpha-Mannosidase

An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.

Year introduced: 2004

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Tree Number(s): D08.811.277.450.625.500

MeSH Unique ID: D043323

Registry Number: EC 3.2.1.24

Entry Terms:

• alpha Mannosidase
• alpha-D-Mannosidase
• alpha D Mannosidase
• alpha-D-Mannoside Mannohydrolase
• alpha D Mannoside Mannohydrolase
• Mannohydrolase, alpha-D-Mannoside
• Neutral alpha-Mannosidase
• alpha-Mannosidase, Neutral
• Neutral alpha Mannosidase
• Lysosomal alpha-Mannosidase
• alpha-Mannosidase, Lysosomal
• Lysosomal alpha Mannosidase
• alpha Mannosidase B
• Mannosidase B, alpha
• LAMAN

Previous Indexing:

• Mannosidases (1980-2003)

See Also:

• alpha-Mannosidosis

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Glycoside Hydrolases
Mannosidases
alpha-Mannosidase