Cytochrome-B(5) Reductase
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
Year introduced: 2004
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Subheadings:
Tree Number(s): D08.811.682.608.191.237, D12.776.331.186
MeSH Unique ID: D042966
Registry Number: EC 1.6.2.2
Entry Terms:
- NADH Cytochrome B5 Reductase
- NADH-Cytochrome B5 Reductase
- B5 Reductase, NADH-Cytochrome
- Methemoglobin Reductase
- Reductase, Methemoglobin
- NADH Methemoglobin Reductase
- Methemoglobin Reductase, NADH
- Reductase, NADH Methemoglobin
- NADH-Ferrihemoglobin Reductase
- NADH Ferrihemoglobin Reductase
- Reductase, NADH-Ferrihemoglobin
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