RNA Interference

A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

Year introduced: 2003

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Tree Number(s): G05.308.203.374.790

MeSH Unique ID: D034622

Entry Terms:

• Interference, RNA
• RNAi
• Posttranscriptional Gene Silencing
• Gene Silencing, Posttranscriptional
• Gene Silencings, Posttranscriptional
• RNA Silencing
• Post-Transcriptional Gene Silencing
• Post Transcriptional Gene Silencing
• Post-Transcriptional Gene Silencings
• Silencing, Post-Transcriptional Gene
• Gene Silencing, Post-Transcriptional
• Gene Silencing, Post Transcriptional
• Cosuppression
• Co-Suppression
• Co Suppression

See Also:

• RNA, Small Interfering
• RNA-Induced Silencing Complex
• RNAi Therapeutics

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Gene Expression Regulation
Epigenesis, Genetic
Gene Silencing
RNA Interference