Activin Receptors
Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.
Year introduced: 2002(1991)
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Subheadings:
Tree Number(s): D08.811.913.696.620.682.700.062, D12.776.476.563.062, D12.776.543.750.750.400.820.500
MeSH Unique ID: D029404
Registry Number: EC 2.7.11.30
Entry Terms:
- Receptors, Activin
- Activin Receptor
- Activin Receptor-like Kinase
- Activin Receptor like Kinase
- Kinase, Activin Receptor-like
- Receptor-like Kinase, Activin
- Activin Receptor-Like Kinases
- Activin Receptor Like Kinases
- Kinases, Activin Receptor-Like
- Receptor-Like Kinases, Activin
- Receptor, Activin
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