RGS Proteins

A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.

Year introduced: 2000

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Tree Number(s): D12.644.360.325.150.750, D12.776.476.325.150.750

MeSH Unique ID: D020710

Entry Terms:

• RGS Protein (G-Protein Signaling)
• Regulators of G-Protein Signaling Proteins
• Regulators of G Protein Signaling Proteins

Previous Indexing:

• Proteins (1989-1999)

Pharmacologic Action:

• GTP Phosphohydrolase Activators

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Intracellular Signaling Peptides and Proteins
GTP-Binding Protein Regulators
GTPase-Activating Proteins
RGS Proteins

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
GTP-Binding Protein Regulators
GTPase-Activating Proteins
RGS Proteins