Buthionine Sulfoximine

A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)

Year introduced: 1997: was BUTHIONINE SULFOXIMINE (NM) 1979-1996

PubMed search builder options

Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): D02.886.030.676.620.125, D12.125.166.676.620.125

MeSH Unique ID: D019328

Registry Number: 5072-26-4

Entry Terms:

• Sulfoximine, Buthionine

Previous Indexing:

• Methionine Sulfoximine (1979-1996)

Pharmacologic Action:

• Antimetabolites
• Antimetabolites, Antineoplastic
• Enzyme Inhibitors
• Radiation-Protective Agents
• Radiation-Sensitizing Agents

All MeSH Categories
Chemicals and Drugs Category
Organic Chemicals
Sulfur Compounds
Amino Acids, Sulfur
Methionine
Methionine Sulfoximine
Buthionine Sulfoximine

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Amino Acids
Amino Acids, Sulfur
Methionine
Methionine Sulfoximine
Buthionine Sulfoximine