Receptors, Leukocyte-Adhesion

Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other and to certain substrata, e.g., the C3bi component of complement. Members of this family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1 ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells.

Year introduced: 1990

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Tree Number(s): D12.776.543.750.705.408.600

MeSH Unique ID: D016028

Entry Terms:

• Receptors, Leukocyte Adhesion
• Leu-CAM Receptor Family
• Family, Leu-CAM Receptor
• Leu CAM Receptor Family
• Receptor Family, Leu-CAM
• Leukocyte-Adhesion Receptor
• Leukocyte Adhesion Receptor
• Receptor, Leukocyte-Adhesion
• Leukocyte-Adhesion Receptors
• Leukocyte Adhesion Receptors
• Leukocyte-Adhesion Receptor Family
• Leukocyte Adhesion Receptor Family

Previous Indexing:

• Antigens (1966-1987)
• Antigens, Differentiation (1988-1989)
• Receptors, Cell Surface (1973-1989)
• Receptors, Immunologic (1980-1989)

See Also:

• Leukocyte-Adhesion Deficiency Syndrome

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Membrane Proteins
Receptors, Cell Surface
Receptors, Immunologic
Integrins
Receptors, Leukocyte-Adhesion
Integrin alphaXbeta2
CD11c Antigen
CD18 Antigens
Lymphocyte Function-Associated Antigen-1
Macrophage-1 Antigen