Complement C5a
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
Year introduced: 2006 (1990)
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Subheadings:
Tree Number(s): D12.776.124.486.274.024.270, D12.776.124.486.274.450.250
MeSH Unique ID: D015936
Registry Number: 80295-54-1
Entry Terms:
- C5a, Complement
- Complement 5a
- Complement Component 5a
- Component 5a, Complement
- C5a Complement
- Complement, C5a
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