Rifampin

A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)

Year introduced: 1973

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Tree Number(s): D03.633.400.811.700, D04.345.295.750.700

MeSH Unique ID: D012293

Registry Number: VJT6J7R4TR

Entry Terms:

• Benemycin
• Rifampicin
• Rifadin
• Rimactane
• Tubocin
• Rimactan

Previous Indexing:

• Rifamycins (1966-1972)

Pharmacologic Action:

• Antibiotics, Antitubercular
• Leprostatic Agents
• Nucleic Acid Synthesis Inhibitors
• Cytochrome P-450 CYP2B6 Inducers
• Cytochrome P-450 CYP2C8 Inducers
• Cytochrome P-450 CYP2C19 Inducers
• Cytochrome P-450 CYP2C9 Inducers
• Cytochrome P-450 CYP3A Inducers

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, Fused-Ring
Heterocyclic Compounds, 4 or More Rings
Rifamycins
Rifampin

All MeSH Categories
Chemicals and Drugs Category
Polycyclic Compounds
Macrocyclic Compounds
Lactams, Macrocyclic
Rifamycins
Rifampin