Podophyllotoxin

A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.

Year introduced: 1973

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Tree Number(s): D02.455.426.559.389.140.450.777, D02.455.426.559.847.638.960.675, D04.615.638.960.675

MeSH Unique ID: D011034

Registry Number: L36H50F353

Entry Terms:

• Podofilox
• Epipodophyllotoxin
• CPH86
• Podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer
• Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer
• Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer
• Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer
• Condylox
• Condyline
• Wartec
• Podofilm
• Warticon
• Podocon-25

Previous Indexing:

• Alkaloids (1966-1972)
• Antineoplastic Agents (1966-1972)

Pharmacologic Action:

• Antineoplastic Agents, Phytogenic
• Keratolytic Agents
• Tubulin Modulators

All MeSH Categories
Chemicals and Drugs Category
Organic Chemicals
Hydrocarbons
Hydrocarbons, Cyclic
Hydrocarbons, Aromatic
Benzene Derivatives
Benzyl Compounds
Lignans
Podophyllotoxin

All MeSH Categories
Chemicals and Drugs Category
Organic Chemicals
Hydrocarbons
Hydrocarbons, Cyclic
Hydrocarbons, Aromatic
Polycyclic Aromatic Hydrocarbons
Naphthalenes
Tetrahydronaphthalenes
Podophyllotoxin
Etoposide

All MeSH Categories
Chemicals and Drugs Category
Polycyclic Compounds
Polycyclic Aromatic Hydrocarbons
Naphthalenes
Tetrahydronaphthalenes
Podophyllotoxin
Etoposide