Methylenetetrahydrofolate Dehydrogenase (NADP)

An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.

Year introduced: 2004(1975)

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Tree Number(s): D08.811.682.662.253

MeSH Unique ID: D008754

Registry Number: EC 1.5.1.5

Entry Terms:

• Methylenetetrahydrofolate Dehydrogenase
• Dehydrogenase, Methylenetetrahydrofolate
• Methylenetetrahydrofolate Dehydrogenase (NADP+)

Previous Indexing:

• Oxidoreductases (1973-1974)
• Tetrahydrofolates (1973-1974)

See Also:

• Formate-Tetrahydrofolate Ligase
• Methenyltetrahydrofolate Cyclohydrolase

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Oxidoreductases
Oxidoreductases Acting on CH-NH Group Donors
Methylenetetrahydrofolate Dehydrogenase (NADP)