Leukoencephalopathy, Progressive Multifocal
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
Year introduced: 1973(1971)
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Tree Number(s): C01.207.245.340.500, C01.207.399.750.500, C01.925.182.525.500, C01.925.256.721.500, C01.925.839.550, C10.228.140.430.520.750.500, C10.228.140.695.750, C10.228.228.245.340.500, C10.228.228.399.750.500, C10.314.450, C10.586.250.520.750.500
MeSH Unique ID: D007968
Entry Terms:
- Leukoencephalopathies, Progressive Multifocal
- Multifocal Leukoencephalopathies, Progressive
- Multifocal Leukoencephalopathy, Progressive
- Progressive Multifocal Leukoencephalopathies
- Encephalitis, JC Polyomavirus
- JC Polyomavirus Encephalitis
- Progressive Multifocal Leukoencephalopathy
- JC Polyomavirus Encephalopathy
- Encephalopathies, JC Polyomavirus
- Encephalopathy, JC Polyomavirus
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