Peptidyl-Dipeptidase A
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide--Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020).
Year introduced: 1994
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Subheadings:
Tree Number(s): D08.811.277.656.350.350.687
MeSH Unique ID: D007703
Registry Number: EC 3.4.15.1
Entry Terms:
- Peptidyl Dipeptidase A
- Peptidase P
- ACE1 Protein
- Antigens, CD143
- Angiotensin Converting Enzyme
- Angiotensin I-Converting Enzyme
- Angiotensin I Converting Enzyme
- Carboxycathepsin
- Kininase A
- Kininase II
- Dipeptidyl Peptidase A
- CD143 Antigens
- ACE1 Angiotensin-Converting Enzyme 1
- ACE1 Angiotensin Converting Enzyme 1
- Dipeptidyl Carboxypeptidase I
- Carboxypeptidase I, Dipeptidyl
- Angiotensin Converting Enzyme 1
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