DNA Topoisomerases, Type II

DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.

Year introduced: 2018(2002)

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Tree Number(s): D08.811.399.403.741

MeSH Unique ID: D004250

Registry Number: EC 5.99.1.3

Entry Terms:

• DNA Topoisomerase II
• Type II DNA Topoisomerase
• DNA Type 2 Topoisomerase
• DNA Topoisomerase (ATP-Hydrolysing)
• Topoisomerase II
• DNA Topoisomerase II alpha
• TOP2A Protein
• Topoisomerase II alpha
• alpha, Topoisomerase II
• DNA Topoisomerase II beta
• TOP2B Protein
• Topoisomerase II beta
• beta, Topoisomerase II

Previous Indexing:

• DNA (1966-1977)
• DNA Replication (1968-1979)
• DNA, Superhelical (1978-1979)
• DNA Untwisting Proteins (1978-1979)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Isomerases
DNA Topoisomerases
DNA Topoisomerases, Type II
DNA Gyrase
DNA Topoisomerase IV