Cystathionine beta-Synthase

A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.

Year introduced: 1991(1975)

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Tree Number(s): D08.811.520.241.300.200

MeSH Unique ID: D003541

Registry Number: EC 4.2.1.22

Entry Terms:

• beta-Synthase, Cystathionine
• Cystathionine beta Synthase
• beta-Thionase
• beta Thionase
• Cystathionine Synthetase
• Synthetase, Cystathionine
• Serine Sulfhydrase
• Sulfhydrase, Serine

Previous Indexing:

• Homocysteine (1973-1974)
• Hydro-Lyases (1973-1974)
• Serine (1973-1974)

See Also:

• Homocystinuria

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Lyases
Carbon-Oxygen Lyases
Hydro-Lyases
Cystathionine beta-Synthase