Complement C8

A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.

Year introduced: 2006 (1975)

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Tree Number(s): D12.776.124.486.274.750

MeSH Unique ID: D003185

Entry Terms:

• C8, Complement
• C8 Complement
• Complement, C8
• Complement 8
• Complement Component 8
• Component 8, Complement
• Complement Component C8 alpha
• Complement Component C8 alpha Chain
• Complement Component C8 beta
• Complement Component C8 beta Chain
• Complement Component C8 gamma
• Complement Component C8 gamma Chain

Previous Indexing:

• Bacteriolysis (1966-1974)
• Complement (1968-1974)
• Hemolysis (1966-1974)

Pharmacologic Action:

• Immunologic Factors

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Blood Proteins
Immunoproteins
Complement System Proteins
Complement C8