Chediak-Higashi Syndrome

A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.

Year introduced: 1971

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Tree Number(s): C11.270.040.772, C15.378.553.774.257, C16.320.798.375, C20.673.774.257, C20.673.795.375

MeSH Unique ID: D002609

Entry Terms:

• Chediak Higashi Syndrome
• Chediak-Steinbrinck-Higashi Syndrome
• Chediak Steinbrinck Higashi Syndrome
• Chediak-Steinbrinck-Higashi Syndromes
• Oculocutaneous Albinism with Leukocyte Defect

Previous Indexing:

• Immunologic Deficiency Syndromes (1968-1970)
• Leukocytes (1966-1970)

See Also:

• Aleutian Mink Disease

All MeSH Categories
Diseases Category
Eye Diseases
Eye Diseases, Hereditary
Albinism
Chediak-Higashi Syndrome
Aleutian Mink Disease

All MeSH Categories
Diseases Category
Hemic and Lymphatic Diseases
Hematologic Diseases
Leukocyte Disorders
Phagocyte Bactericidal Dysfunction
Chediak-Higashi Syndrome

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Diseases Category
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Genetic Diseases, Inborn
Primary Immunodeficiency Diseases
Chediak-Higashi Syndrome

All MeSH Categories
Diseases Category
Immune System Diseases
Immunologic Deficiency Syndromes
Phagocyte Bactericidal Dysfunction
Chediak-Higashi Syndrome
Aleutian Mink Disease

All MeSH Categories
Diseases Category
Immune System Diseases
Immunologic Deficiency Syndromes
Primary Immunodeficiency Diseases
Chediak-Higashi Syndrome