Autophagy
The segregation and degradation of various cytoplasmic constituents via engulfment by MULTIVESICULAR BODIES; VACUOLES; or AUTOPHAGOSOMES and their digestion by LYSOSOMES. It plays an important role in BIOLOGICAL METAMORPHOSIS and in the removal of bone by OSTEOCLASTS. Defective autophagy is associated with various diseases, including NEURODEGENERATIVE DISEASES and cancer.
Year introduced: 2006(1979)
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Subheadings:
Tree Number(s): G04.011
MeSH Unique ID: D001343
Entry Terms:
- Autophagocytosis
- Autophagy, Cellular
- Cellular Autophagy
- Lipophagy
- Ribophagy
- Reticulophagy
- ER-Phagy
- ER Phagy
- Nucleophagy
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