Amyotrophic Lateral Sclerosis
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
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Subheadings:
Tree Number(s): C10.228.854.139, C10.574.562.250, C10.574.950.050, C10.668.467.250, C18.452.845.800.050
MeSH Unique ID: D000690
Entry Terms:
- Sclerosis, Amyotrophic Lateral
- ALS - Amyotrophic Lateral Sclerosis
- ALS Amyotrophic Lateral Sclerosis
- Gehrig's Disease
- Gehrig Disease
- Gehrigs Disease
- Lou Gehrig Disease
- Motor Neuron Disease, Amyotrophic Lateral Sclerosis
- Lou Gehrig's Disease
- Lou-Gehrigs Disease
- Disease, Lou-Gehrigs
- Charcot Disease
- Amyotrophic Lateral Sclerosis With Dementia
- Dementia With Amyotrophic Lateral Sclerosis
- Amyotrophic Lateral Sclerosis, Guam Form
- Guam Disease
- Disease, Guam
- Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1
- Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1
- Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam
- Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam
- Guam Form of Amyotrophic Lateral Sclerosis