Pradimicins and Benanomicins
Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria, e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g., D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins and benanomicins have anti-HIV activities.
Year introduced: 2024
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Subheadings:
Tree Number(s): D02.455.426.559.847.562.050.825, D02.540.576.750, D02.806.550.469, D04.345.674.750, D04.615.562.050.825, D09.408.051.059.825
MeSH Unique ID: D000095643
Entry Terms:
- Pradimicin-Like Polyketides
- Pradimicin Like Polyketides
- Pradimicin-Type Polyphenols
- Pradimicin Type Polyphenols
- Benanomicins and Pradimicins
- Pradimicin and Benanomicin Antibiotics
- Benanomicin and Pradimicin Antibiotics
- Pradimicin Antibiotics
- Pradimicins
- Benanomicin Antibiotics
- Benanomicins
- Pradimicinones
- Benanomicinones