T-Cell Exhaustion

Progressive deterioration of T-cell function due to chronic antigen stimulation and inflammatory signals, e.g., CHRONIC INFECTION and CANCER. T-cell exhaustion is characterized by weakened immune system, e.g., dysfunctional MEMORY T CELLS differentiation and EPIGENETIC REPRESSION of IMMUNOLOGIC MEMORY effector functions.

Year introduced: 2023

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Tree Number(s): G12.590.500

MeSH Unique ID: D000094383

Entry Terms:

• Exhaustion, T-Cell
• T Cell Exhaustion
• T-Lymphocyte Exhaustion
• Exhaustions, T-Lymphocyte
• Exhaustion, T-Lymphocyte
• T Lymphocyte Exhaustion
• T-Lymphocyte Exhaustions

See Also:

• Lymphocyte Depletion
• T-Cell Senescence

All MeSH Categories
Phenomena and Processes Category
Immune System Phenomena
Immune System Exhaustion
T-Cell Exhaustion