mu-Crystallins
A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS and in neural tissue, muscle, and kidney in humans. It is not a structural protein accounting for the transparency of the human lens unlike other crystallins but instead plays a role in thyroid hormone bioavailability. It is also a cerebral ketimine reductase which reduces cyclic imines (e.g., DELTA(1)-PIPERIDINE-2-CARBOXYLIC ACID; CYSTATHIONINE KETIMINE and LANTHIONINE KETIMINE) in mammalian brain. Mutations in mu-crystallins are associated with an autosomal dominant NONSYNDROMIC DEAFNESS.
Year introduced: 2022(1992)
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Subheadings:
Tree Number(s): D08.811.682.662.436, D12.776.306.366.888
MeSH Unique ID: D000090803
Registry Number: EC 1.5.1.25
Entry Terms:
- mu Crystallins
- Crystallin mu
- mu, Crystallin
- Ketimine Reductase mu-Crystallin
- Ketimine Reductase mu Crystallin
- mu-Crystallin, Ketimine Reductase
- Reductase mu-Crystallin, Ketimine
- CRYM Protein
- Protein, CRYM
- THBP Protein
- Protein, THBP
- NADP-Regulated Thyroid Hormone Binding Protein
- NADP Regulated Thyroid Hormone Binding Protein