Synucleinopathies
Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.
Year introduced: 2020
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Subheadings:
Tree Number(s): C10.574.928, C18.452.845.650
MeSH Unique ID: D000080874
Entry Terms:
- Synucleinopathy
- alpha-Synucleinopathies
- alpha Synucleinopathies
- alpha-Synucleinopathy
- a-Synucleinopathies
- a-Synucleinopathy
- alpha Synuclein Pathology
- alpha Synuclein Pathologies
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