Tuberous Sclerosis Complex 1 Protein

An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS.

Year introduced: 2019 (1997)

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Tree Number(s): D12.644.360.925, D12.776.476.932, D12.776.624.776.766

MeSH Unique ID: D000077004

Entry Terms:

• Hamartin

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Intracellular Signaling Peptides and Proteins
Tuberous Sclerosis Complex 1 Protein

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Tuberous Sclerosis Complex 1 Protein

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Neoplasm Proteins
Tumor Suppressor Proteins
Tuberous Sclerosis Complex 1 Protein