T-Lymphoma Invasion and Metastasis-inducing Protein 1

A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT.

Year introduced: 2018

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Tree Number(s): D12.644.360.325.300.850, D12.776.476.325.300.850

MeSH Unique ID: D000075684

Entry Terms:

• T Lymphoma Invasion and Metastasis inducing Protein 1
• TIAM1 Protein
• TIAM-1 Protein
• TIAM 1 Protein

Previous Indexing:

• Guanine Nucleotide Exchange Factors (2007-2017)

See Also:

• PDZ Domains
• Pleckstrin Homology Domains

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Intracellular Signaling Peptides and Proteins
GTP-Binding Protein Regulators
Guanine Nucleotide Exchange Factors
T-Lymphoma Invasion and Metastasis-inducing Protein 1

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
GTP-Binding Protein Regulators
Guanine Nucleotide Exchange Factors
T-Lymphoma Invasion and Metastasis-inducing Protein 1