Deubiquitinating Enzyme CYLD
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.
Year introduced: 2018
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Subheadings:
Tree Number(s): D08.811.037.375, D12.776.624.776.482
MeSH Unique ID: D000074749
Registry Number: EC 3.4.19.12
Entry Terms:
- CYLD, Deubiquitinating Enzyme
- CYLD Protein
- Cylindromatosis Protein
- Deubiquitinating Enzyme Cylindromatosis
- Cylindromatosis, Deubiquitinating Enzyme
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