Valosin Containing Protein
A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.
Year introduced: 2018 (1991)
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Subheadings:
Tree Number(s): D08.811.277.040.013.500.750, D08.811.277.040.025.024.750, D12.776.157.025.750.750, D12.776.167.800
MeSH Unique ID: D000074405
Registry Number: EC 3.6.4.6
Entry Terms:
- CDC48 Protein
- Valosine-Containing Protein
- Valosine Containing Protein
- Cell Cycle Protein CDC48p
- p97 Valosin-Containing Protein
- p97 Valosin Containing Protein
- Valosin-Containing Protein, p97
- Valosin-Containing Protein
- Cell Cycle Protein CDC48