Zinc Finger Protein Gli3

A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.

Year introduced: 2018

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Tree Number(s): D12.776.260.522.875, D12.776.260.703.900, D12.776.930.375.875, D12.776.930.780.972

MeSH Unique ID: D000074290

Entry Terms:

• GLI-Kruppel Family Member 3 Protein
• GLI Kruppel Family Member 3 Protein
• Glioma-Associated Oncogene Family Zinc Finger 3 Protein
• Glioma Associated Oncogene Family Zinc Finger 3 Protein

Previous Indexing:

• DNA-Binding Proteins (1990-2017)
• Kruppel-Like Transcription Factors (2006-2017)
• Nerve Tissue Proteins (2006-2017)
• Transcription Factors (1990-2017)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
DNA-Binding Proteins
Kruppel-Like Transcription Factors
Zinc Finger Protein Gli3

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
DNA-Binding Proteins
Repressor Proteins
Zinc Finger Protein Gli3

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Transcription Factors
Kruppel-Like Transcription Factors
Zinc Finger Protein Gli3

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Transcription Factors
Repressor Proteins
Zinc Finger Protein Gli3