Transcription Factor 4

A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.

Year introduced: 2018

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Tree Number(s): D12.776.260.108.092.937, D12.776.930.125.500.937

MeSH Unique ID: D000073940

Entry Terms:

• TCF-4 Protein
• TCF 4 Protein
• TCF4 Transcription Factor
• Transcription Factor, TCF4
• TCF-4 Transcription Factor
• TCF 4 Transcription Factor
• Transcription Factor, TCF-4

Previous Indexing:

• Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (2010-2017)
• Transcription Factors (2008-2017)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
DNA-Binding Proteins
Basic-Leucine Zipper Transcription Factors
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Transcription Factor 4

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Transcription Factors
Basic Helix-Loop-Helix Transcription Factors
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Transcription Factor 4