Protein Deglycase DJ-1

A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.

Year introduced: 2017

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Tree Number(s): D08.811.277.785, D12.776.705.875

MeSH Unique ID: D000071617

Registry Number: EC 3.1.2.-

Entry Terms:

• DJ-1, Protein Deglycase
• PARK7 Protein
• DJ-1-PARK7 Protein
• DJ 1 PARK7 Protein
• Parkinsonism Associated Deglycase
• Deglycase, Parkinsonism Associated
• Parkinson Protein 7
• DJ1 Protein
• DJ-1 Protein
• DJ 1 Protein

Previous Indexing:

• Intracellular Signaling Peptides and Proteins (1997-2016)
• Oncogene Proteins (1997-2016)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Protein Deglycase DJ-1

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Parkinson Disease Associated Proteins
Protein Deglycase DJ-1