N-Myc Proto-Oncogene Protein
A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.
Year introduced: 2017
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Subheadings:
Tree Number(s): D12.776.260.103.500.625, D12.776.260.108.092.625, D12.776.624.664.700.158, D12.776.930.125.500.563, D12.776.930.127.092.625
MeSH Unique ID: D000071447
Entry Terms:
- N Myc Proto Oncogene Protein
- Proto-Oncogene Protein, N-Myc
- N-Myc Protein
- N Myc Protein
- MYCN Protein
- NMYC Protein
- Class E Basic Helix-Loop-Helix Protein 37
- Class E Basic Helix Loop Helix Protein 37
- BHLHE37 Protein
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